| IBB | ISHARES BIOTECHNOLOGY ETF | $9.10B | 0.44% | Feb 5, 2001 | 83.93% |
| BIB | PROSHARES ULTRA NASDAQ BIOTECHNOLOGY | $84M | N/A | Apr 6, 2010 | 55.56% |
| BBH | VANECK BIOTECH ETF | $396M | 0.35% | Dec 20, 2011 | 49.86% |
| XBI | STATE STREET(R) SPDR(R) S&P(R) BIOTECH ETF | $11B | 0.35% | Jan 31, 2006 | 40.57% |
| PBE | INVESCO BIOTECHNOLOGY & GENOME ETF | $278M | 0.58% | Jun 23, 2005 | 37.14% |
| FTXH | FIRST TRUST NASDAQ PHARMACEUTICALS ETF | $36M | 0.60% | Sep 20, 2016 | 36.99% |
| BBP | VIRTUS BIOTECH ETF | $87M | 0.34% | Dec 16, 2014 | 35.97% |
| FBT | FIRST TRUST NYSE ARCA BIOTECHNOLOGY INDEX FUND | $2.80B | 0.55% | Jun 19, 2006 | 30.77% |
| TBXU | Trust Direxion Daily Biotech Top 5 Bull 2X ETF | $3M | N/A | Sep 30, 2025 | 29.45% |
| LABU | DIREXION DAILY S&P BIOTECH BULL 3X SHARES DIREXION DAILY S&P BIOTECH BULL 3X SHARES | $678M | N/A | May 28, 2015 | 28.11% |
| WDNA | WISDOMTREE BIOREVOLUTION FUND | $3M | 0.45% | Jun 1, 2021 | 26.15% |
| FMED | FIDELITY DISRUPTIVE MEDICINE ETF | $46M | 0.50% | Apr 16, 2020 | 25.88% |
| HELX | FRANKLIN GENOMIC ADVANCEMENTS ETF | $28M | 0.50% | Feb 25, 2020 | 24.91% |
| FXH | FIRST TRUST HEALTH CARE ALPHADEX FUND | $959M | 0.61% | May 8, 2007 | 24.76% |
| BMED | BlackRock Future Health ETF | $11M | 0.55% | Sep 29, 2020 | 23.66% |
| PTH | INVESCO DORSEY WRIGHT HEALTHCARE MOMENTUM ETF | $135M | 0.60% | Oct 12, 2006 | 23.16% |
| MEDI | HARBOR HEALTH CARE ETF | $43M | 0.80% | Nov 16, 2022 | 21.65% |
| PBPH | Portfolio Building Block World Pharma and Biotech Index ETF | $859M | 0.13% | Nov 25, 2025 | 21.14% |
| PJP | INVESCO PHARMACEUTICALS ETF | $356M | 0.57% | Jun 23, 2005 | 21.00% |
| HRTS | TEMA HEART & HEALTH ETF | $54M | 0.75% | Nov 20, 2023 | 19.55% |
| HTEC | ROBO GLOBAL(R) HEALTHCARE TECHNOLOGY AND INNOVATION ETF | $60M | 0.68% | Jun 24, 2019 | 18.89% |
| QQQJ | INVESCO NASDAQ NEXT GEN 100 ETF | $1.10B | 0.15% | Oct 13, 2020 | 18.49% |
| IDNA | ISHARES GENOMICS IMMUNOLOGY AND HEALTHCARE ETF | $194M | 0.47% | Jun 11, 2019 | 18.21% |
| VHT | VANGUARD HEALTH CARE INDEX FUND ETF SHARES | $20B | 0.09% | Jan 26, 2004 | 18.06% |
| GDOC | GOLDMAN SACHS FUTURE HEALTH CARE EQUITY ETF | $19M | 0.75% | Nov 9, 2021 | 17.19% |
| GNOM | GLOBAL X GENOMICS & BIOTECHNOLOGY ETF | $77M | 0.50% | Apr 5, 2019 | 17.18% |
| IYH | ISHARES U.S. HEALTHCARE ETF | $3.20B | 0.38% | Jun 12, 2000 | 17.04% |
| IWO | ISHARES RUSSELL 2000 GROWTH ETF | $15B | 0.24% | Jul 24, 2000 | 16.99% |
| BBC | VIRTUS BIOTECH CLINICAL TRIALS ETF | $53M | 0.65% | Dec 16, 2014 | 16.96% |
| CANC | TEMA ONCOLOGY ETF | $190M | 0.75% | Aug 14, 2023 | 16.67% |
| PWS | PACER WEALTHSHIELD ETF | $25M | 0.60% | Dec 11, 2017 | 16.34% |
| RSPH | INVESCO S&P 500 EQUAL WEIGHT HEALTH CARE ETF | $705M | 0.40% | Nov 1, 2006 | 13.50% |
| AGNG | GLOBAL X AGING POPULATION ETF | $85M | 0.50% | May 9, 2016 | 13.42% |
| ACSG | AMERICAN CENTURY SMALL CAP GROWTH INSIGHTS ETF | $25M | 0.49% | Oct 14, 2025 | 13.41% |
| MEDX | HORIZON KINETICS MEDICAL ETF | $19M | 0.85% | Sep 30, 1999 | 13.05% |
| FHLC | FIDELITY MSCI HEALTH CARE INDEX ETF | $3.20B | 0.08% | Oct 21, 2013 | 12.88% |
| FSEG | FIDELITY ENHANCED SMALL CAP GROWTH ETF | $6M | 0.28% | Apr 28, 2026 | 12.80% |
| MMSC | FIRST TRUST MULTI-MANAGER SMALL CAP OPPORTUNITIES ETF | $55M | 0.95% | Oct 13, 2021 | 12.72% |
| FNY | FIRST TRUST MID CAP GROWTH ALPHADEX FUND | $615M | 0.73% | Apr 19, 2011 | 12.36% |
| ESSC | EVENTIDE SMALL CAP ETF | $30M | 0.49% | Sep 29, 2025 | 12.28% |
| VFMO | VANGUARD U.S. MOMENTUM FACTOR ETF ETF SHARES | $2B | 0.13% | Feb 13, 2018 | 11.90% |
| PINK | SIMPLIFY HEALTH CARE ETF | $359M | 0.51% | Oct 7, 2021 | 11.63% |
| TMFX | MOTLEY FOOL NEXT INDEX ETF | $34M | 0.50% | Dec 30, 2021 | 11.44% |
| FESM | FIDELITY ENHANCED SMALL CAP ETF | $5.80B | 0.28% | Dec 20, 2007 | 11.40% |
| TNXT | T. ROWE PRICE INNOVATION LEADERS ETF | $18M | 0.49% | Jan 28, 2026 | 11.33% |
| QFRD | PACER S&P 500 QUALITY FCF R&D LEADERS ETF | $1M | 0.49% | Jan 12, 2026 | 11.12% |
| XLV | STATE STREET(R) HEALTH CARE SELECT SECTOR SPDR(R) ETF | $41B | 0.08% | Dec 16, 1998 | 11.10% |
| TRUH | VANECK HEALTHCARE TRUSECTOR ETF | $1M | 0.10% | Apr 1, 2026 | 11.00% |
| XPH | STATE STREET(R) SPDR(R) S&P(R) PHARMACEUTICALS ETF | $428M | 0.35% | Jun 19, 2006 | 10.92% |
| THNR | Amplify Weight Loss Drug & Treatment ETF | $4M | 0.59% | May 20, 2024 | 10.89% |
| IHE | ISHARES U.S. PHARMACEUTICALS ETF | $1.10B | 0.38% | May 1, 2006 | 10.88% |
| QNXT | ISHARES NASDAQ-100 EX TOP 30 ETF | $19M | 0.20% | Oct 23, 2024 | 10.64% |
| JDOC | JPMORGAN HEALTHCARE LEADERS ETF | $9M | 0.65% | Nov 1, 2023 | 10.57% |
| VTWG | VANGUARD RUSSELL 2000 GROWTH INDEX FUND ETF SHARES | $1.80B | 0.06% | Sep 20, 2010 | 10.47% |
| PILL | DIREXION DAILY PHARMACEUTICAL & MEDICAL BULL 3X SHARES | $20M | N/A | Nov 15, 2017 | 10.28% |
| RSSL | GLOBAL X RUSSELL 2000 ETF | $1.50B | 0.08% | Jun 4, 2024 | 10.25% |
| IQSM | NYLI CANDRIAM U.S. MID CAP EQUITY ETF | $337M | 0.15% | Oct 24, 2022 | 10.06% |
| SBIO | ALPS MEDICAL BREAKTHROUGHS ETF | $190M | 0.50% | Dec 30, 2014 | 10.06% |
| IBRN | ISHARES NEUROSCIENCE AND HEALTHCARE ETF | $6M | 0.47% | Aug 24, 2022 | 10.03% |
| TMSL | T. ROWE PRICE SMALL-MID CAP ETF | $2.70B | 0.55% | Jun 14, 2023 | 9.84% |
| GSSC | GOLDMAN SACHS ACTIVEBETA(R) U.S. SMALL CAP EQUITY ETF | $1.10B | 0.20% | Jun 28, 2017 | 9.67% |
| QQXT | FIRST TRUST NASDAQ-100 EX-TECHNOLOGY SECTOR INDEX FUND | $166M | 0.57% | Feb 8, 2007 | 9.57% |
| BBSC | JPMORGAN BETABUILDERS U.S. SMALL CAP EQUITY ETF | $744M | 0.09% | Nov 16, 2020 | 9.40% |
| QMOM | ALPHA ARCHITECT U.S. QUANTITATIVE MOMENTUM ETF | $444M | 0.28% | Dec 1, 2015 | 9.35% |
| LFSC | F/M EMERALD LIFE SCIENCES INNOVATION ETF | $122M | 0.54% | Oct 30, 2024 | 9.10% |
| RUSC | RUSSELL INVESTMENTS U.S. SMALL CAP EQUITY ETF | $79M | 0.64% | May 13, 2025 | 8.98% |
| VBK | VANGUARD SMALL-CAP GROWTH INDEX FUND ETF SHARES | $47B | 0.05% | Jan 26, 2004 | 8.96% |
| VTWO | VANGUARD RUSSELL 2000 INDEX FUND ETF SHARES | $19B | 0.06% | Sep 20, 2010 | 8.78% |
| ISCG | ISHARES MORNINGSTAR SMALL-CAP GROWTH ETF | $1B | 0.06% | Jun 28, 2004 | 8.59% |
| GURU | GLOBAL X GURU INDEX ETF | $64M | 0.75% | Jun 4, 2012 | 8.57% |
| COWG | PACER US LARGE CAP CASH COWS GROWTH LEADERS ETF | $2.40B | 0.49% | Dec 21, 2022 | 8.45% |
| RKSG | RUK STRATEGIC GROWTH ETF | $2M | 0.50% | Apr 6, 2026 | 8.35% |
| FAD | FIRST TRUST MULTI CAP GROWTH ALPHADEX FUND | $580M | 0.63% | May 8, 2007 | 8.34% |
| IXJ | ISHARES GLOBAL HEALTHCARE ETF | $3.80B | 0.40% | Nov 13, 2001 | 8.32% |
| BUL | PACER US CASH COWS GROWTH ETF | $127M | 0.60% | May 2, 2019 | 8.16% |
| MFIG | MOTLEY FOOL INNOVATIVE GROWTH FACTOR ETF | $12M | 0.50% | Dec 8, 2025 | 8.12% |
| TAX | CAMBRIA TAX AWARE ETF | $26M | 0.54% | Dec 17, 2024 | 8.07% |
| RXL | ProShares Ultra Health Care 2X Shares | $79M | N/A | Jan 30, 2007 | 7.99% |
| STXK | STRIVE SMALL-CAP ETF | $84M | 0.18% | Nov 9, 2022 | 7.85% |
| SMLF | ISHARES U.S. SMALL-CAP EQUITY FACTOR ETF | $4.20B | 0.15% | Apr 28, 2015 | 7.83% |
| ARKG | ARK GENOMIC REVOLUTION ETF | $1.70B | 0.75% | Oct 31, 2014 | 7.80% |
| FFTY | INNOVATOR IBD(R) 50 ETF | $94M | 0.80% | Apr 8, 2015 | 7.74% |
| CURE | DIREXION DAILY HEALTHCARE BULL 3X SHARES | $169M | N/A | Jun 15, 2011 | 7.58% |
| FYC | FIRST TRUST SMALL CAP GROWTH ALPHADEX FUND | $1.30B | 0.70% | Apr 19, 2011 | 7.57% |
| SGRW | HARBOR ACTIVE SMALL CAP GROWTH ETF | $5M | 0.80% | Jan 14, 2026 | 7.50% |
| PSC | Principal U.S. Small-Cap ETF | $2.30B | 0.38% | Sep 21, 2016 | 7.48% |
| MDYG | STATE STREET(R) SPDR(R) S & P 400(TM) MID CAP GROWTH ETF | $2.90B | 0.15% | Nov 8, 2005 | 7.45% |
| FDG | AMERICAN CENTURY FOCUSED DYNAMIC GROWTH ETF | $408M | 0.45% | Mar 31, 2020 | 7.45% |
| DRUP | Graniteshares Nasdaq Select Disruptors ETF | $47M | 0.60% | Oct 7, 2019 | 7.33% |
| IJK | ISHARES S&P MID-CAP 400 GROWTH ETF | $11B | 0.17% | Jul 24, 2000 | 7.32% |
| FEMG | FIDELITY ENHANCED MID CAP GROWTH ETF | $7M | 0.23% | Apr 28, 2026 | 7.22% |
| SAGP | STRATEGAS GLOBAL POLICY OPPORTUNITIES ETF | $77M | 0.65% | Jan 25, 2022 | 7.13% |
| IVOG | VANGUARD S&P MID-CAP 400 GROWTH INDEX FUND ETF SHARES | $1.90B | 0.10% | Sep 7, 2010 | 7.06% |
| AVIE | AVANTIS INFLATION FOCUSED EQUITY ETF | $10M | 0.25% | Sep 27, 2022 | 7.05% |
| ILDR | FIRST TRUST INNOVATION LEADERS ETF | $302M | 0.75% | May 25, 2021 | 7.05% |
| UWM | PROSHARES ULTRA RUSSELL2000 | $279M | N/A | Jan 23, 2007 | 7.03% |
| ISCB | ISHARES MORNINGSTAR SMALL-CAP ETF | $287M | 0.04% | Jun 28, 2004 | 7.02% |
| RFG | INVESCO S&P MIDCAP 400 PURE GROWTH ETF | $359M | 0.35% | Mar 1, 2006 | 7.01% |
| GSC | GOLDMAN SACHS SMALL CAP CORE EQUITY ETF | $300M | 0.75% | Oct 3, 2023 | 6.91% |
| XMHQ | INVESCO S&P MIDCAP QUALITY ETF | $5.40B | 0.25% | Dec 1, 2006 | 6.88% |
| IWN | ISHARES RUSSELL 2000 VALUE ETF | $15B | 0.24% | Jul 24, 2000 | 6.83% |
| BKMC | BNY MELLON US MID CAP CORE EQUITY ETF | $670M | 0.04% | Apr 7, 2020 | 6.79% |
| LSGR | NATIXIS LOOMIS SAYLES FOCUSED GROWTH ETF | $839M | 0.59% | Jun 29, 2023 | 6.77% |
| DWAS | INVESCO DORSEY WRIGHT SMALLCAP MOMENTUM ETF | $455M | 0.60% | Jul 19, 2012 | 6.76% |
| ESML | ISHARES ESG AWARE MSCI USA SMALL-CAP ETF | $2.90B | 0.17% | Apr 10, 2018 | 6.70% |
| PDP | INVESCO DORSEY WRIGHT MOMENTUM ETF | $2.10B | 0.62% | Mar 1, 2007 | 6.68% |
| JSMD | JANUS HENDERSON SMALL/MID CAP GROWTH ALPHA ETF | $1.10B | 0.30% | Feb 23, 2016 | 6.67% |
| QMID | WISDOMTREE U.S. MIDCAP QUALITY GROWTH FUND | $2M | 0.38% | Jan 23, 2024 | 6.64% |
| TECB | ISHARES U.S. TECH BREAKTHROUGH MULTISECTOR ETF | $478M | 0.30% | Jan 8, 2020 | 6.53% |
| QQQG | PACER NASDAQ 100 TOP 50 CASH COWS GROWTH LEADERS ETF | $22M | 0.49% | Aug 19, 2024 | 6.43% |
| ABOT | ABACUS FCF INNOVATION LEADERS ETF | $5M | 0.39% | Dec 7, 2020 | 6.39% |
| FCPI | FIDELITY STOCKS FOR INFLATION ETF | $276M | 0.15% | Nov 5, 2019 | 6.33% |
| RND | FIRST TRUST BLOOMBERG R&D LEADERS ETF | $5M | 0.60% | Apr 30, 2024 | 6.28% |
| FLQM | FRANKLIN U.S. MID CAP MULTIFACTOR INDEX ETF | $1.50B | 0.30% | Apr 26, 2017 | 6.27% |
| JSML | JANUS HENDERSON SMALL CAP GROWTH ALPHA ETF | $450M | 0.30% | Feb 23, 2016 | 6.21% |
| SCHM | SCHWAB U.S. MID-CAP ETF | $15B | 0.03% | Jan 13, 2011 | 6.20% |
| SCHA | SCHWAB U.S. SMALL-CAP ETF | $24B | 0.03% | Nov 3, 2009 | 6.19% |
| SDG | iShares MSCI Global Sustainable Development Goals ETF | $170M | 0.50% | Apr 20, 2016 | 6.19% |
| PRFZ | INVESCO FTSE RAFI US 1500 SMALL-MID ETF | $2.90B | 0.34% | Sep 20, 2006 | 6.16% |
| TCAF | T. ROWE PRICE CAPITAL APPRECIATION EQUITY ETF | $7.40B | 0.31% | Jun 14, 2023 | 6.16% |
| VTWV | VANGUARD RUSSELL 2000 VALUE INDEX FUND ETF SHARES | $1.40B | 0.06% | Sep 20, 2010 | 6.10% |
| STXM | STRIVE MID-CAP ETF | $22M | 0.18% | Apr 10, 2024 | 6.03% |
| QQEW | FIRST TRUST NASDAQ-100 SELECT EQUAL WEIGHT ETF | $1.80B | 0.55% | Apr 19, 2006 | 6.03% |
| SMMV | ISHARES MSCI USA SMALL-CAP MIN VOL FACTOR ETF | $290M | 0.20% | Sep 7, 2016 | 6.01% |
| VFMF | VANGUARD U.S. MULTIFACTOR ETF ETF SHARES | $703M | 0.18% | Feb 13, 2018 | 6.00% |
| SAMM | STRATEGAS MACRO MOMENTUM ETF | $30M | 0.65% | Apr 4, 2024 | 5.95% |
| EKG | FIRST TRUST NASDAQ LUX DIGITAL HEALTH SOLUTIONS ETF | $3M | 0.65% | Mar 22, 2022 | 5.94% |
| LSEQ | HARBOR LONG-SHORT EQUITY ETF | $17M | 2.28% | Dec 4, 2023 | 5.93% |
| KONG | FORMIDABLE FORTRESS ETF | $22M | 0.89% | Jul 21, 2021 | 5.83% |
| FYX | FIRST TRUST SMALL CAP CORE ALPHADEX FUND | $1.40B | 0.58% | May 8, 2007 | 5.83% |
| PSCH | INVESCO S&P SMALLCAP HEALTH CARE ETF | $159M | 0.29% | Apr 7, 2010 | 5.82% |
| SCDS | JPMORGAN FUNDAMENTAL DATA SCIENCE SMALL CORE ETF | $9M | 0.40% | Aug 7, 2024 | 5.80% |
| FRTY | ALGER MID CAP 40 ETF | $154M | 0.60% | Feb 26, 2021 | 5.72% |
| BKSE | BNY MELLON US SMALL CAP CORE EQUITY ETF | $87M | 0.04% | Apr 7, 2020 | 5.71% |
| OMFS | INVESCO RUSSELL 2000(R) DYNAMIC MULTIFACTOR ETF | $287M | 0.39% | Nov 8, 2017 | 5.67% |
| USMF | WISDOMTREE U.S. MULTIFACTOR FUND | $310M | 0.28% | Jun 29, 2017 | 5.65% |
| FNX | FIRST TRUST MID CAP CORE ALPHADEX FUND | $1.40B | 0.62% | May 8, 2007 | 5.65% |
| FPX | FIRST TRUST US EQUITY OPPORTUNITIES ETF | $1.70B | 0.57% | Apr 12, 2006 | 5.60% |
| VXF | VANGUARD EXTENDED MARKET INDEX FUND ETF SHARES | $98B | 0.05% | Dec 27, 2001 | 5.56% |
| COWZ | PACER US CASH COWS 100 ETF | $18B | 0.49% | Dec 16, 2016 | 5.56% |
| ELCV | EVENTIDE HIGH DIVIDEND ETF | $256M | 0.49% | Sep 30, 2024 | 5.54% |
| SEIS | SEI SELECT SMALL CAP ETF | $582M | 0.55% | Oct 8, 2024 | 5.53% |
| GFLW | VICTORYSHARES FREE CASH FLOW GROWTH ETF | $877M | 0.39% | Dec 3, 2024 | 5.48% |
| GRPM | INVESCO S&P MIDCAP 400 GARP ETF | $473M | 0.35% | Dec 3, 2010 | 5.48% |
| QQQE | DIREXION NASDAQ-100(R) EQUAL WEIGHTED INDEX SHARES | $1.40B | 0.35% | Mar 21, 2012 | 5.43% |
| LST | LEUTHOLD SELECT INDUSTRIES ETF | $120M | 0.65% | Jun 19, 2000 | 5.42% |
| VFLO | VICTORYSHARES FREE CASH FLOW ETF | $7.80B | 0.39% | Jun 21, 2023 | 5.39% |
| IWM | ISHARES RUSSELL 2000 ETF | $83B | 0.19% | May 22, 2000 | 5.33% |
| GPT | INTELLIGENT ALPHA ATLAS ETF | $24M | 0.69% | Sep 17, 2024 | 5.33% |
| SXQG | ETC 6 MERIDIAN QUALITY GROWTH ETF | $63M | 0.55% | May 10, 2021 | 5.30% |
| DURA | VANECK DURABLE HIGH DIVIDEND ETF | $37M | 0.30% | Oct 30, 2018 | 5.29% |
| LGCF | THEMES US CASH FLOW CHAMPIONS ETF | $2M | 0.29% | Dec 12, 2023 | 5.28% |
| QEW | Invesco QQQ Equal Weight ETF | $21M | 0.25% | Mar 16, 2026 | 5.19% |
| FSCC | FEDERATED HERMES MDT SMALL CAP CORE ETF | $309M | 0.36% | Jul 30, 2024 | 5.18% |
| DSTL | DISTILLATE U.S. FUNDAMENTAL STABILITY & VALUE ETF | $2.10B | 0.39% | Oct 23, 2018 | 5.18% |
| FTQI | FIRST TRUST NASDAQ BUYWRITE INCOME ETF | $926M | 0.75% | Jan 6, 2014 | 5.17% |
| ADDS | Hedgeye Index Adds | $6M | 0.70% | May 27, 2026 | 5.14% |
| FSGS | First Trust Small Cap US Equity Select ETF | $29M | 0.61% | Jun 20, 2017 | 5.12% |
| USVM | VICTORYSHARES US SMALL MID CAP VALUE MOMENTUM ETF FORMERLY VICTORYSHARES USAA MSCI USA SMALL CAP VALUE MOMENTUM ETF | $1.70B | 0.29% | Oct 24, 2017 | 5.09% |
| AFSM | FIRST TRUST ACTIVE FACTOR SMALL CAP ETF | $115M | 0.75% | Dec 3, 2019 | 5.04% |
| FFND | ONE GLOBAL ETF | $101M | 1.00% | Aug 23, 2021 | 5.02% |
| TBG | TBG DIVIDEND FOCUS ETF | $239M | 0.45% | Nov 6, 2023 | 5.01% |